Maternal origin of monosomy 21 derived from ICSI
نویسندگان
چکیده
منابع مشابه
Paternal origin of trisomy 21 following intracytoplasmic sperm injection (ICSI).
One important aspect in the debate on the genetic risks associated with intracytoplasmic sperm injection (ICSI) is the possible increased rate of chromosomal abnormalities in resulting pregnancies. ICSI was performed in a 27 year old man with asthenoteratozoospermia and his 25 year old wife. There was a spontaneous miscarriage at 9 weeks of gestation. Cytogenetic investigation revealed trisomy ...
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An account is given of the cytogenetic investigations of a girl with Down's syndrome found to have a dicentric duplication of chromosome 21. This tandem type of rearrangement was interpreted as a recombinant derived from a single meiotic crossover between a maternal ring 21 and its normal homologue. A population of cells was also found in which breakage of the dicentric resulted in a chromosome...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2001
ISSN: 1460-2350
DOI: 10.1093/humrep/16.6.1100